Allergy Information

What are Allergies?
How Allergies Develop
The Histamine Connection
Pollen and Allergies
Seasonal Allergic Rhinitis or Hayfever
Perennial allergies

What are Allergies?
Simply put, an allergy is a response by your body to something that is ordinarily harmless. The purpose of the immune system is to recognize harmful infection-causing invaders and to get rid of them. However, for some people, the immune system overreacts to ordinarily harmless substances like indoor allergens such as pet dander, pollen, dust, and mold and outdoor allergens such as pollen from grass, trees and weeds. These people have "allergies." Their bodies attempt to expel these ordinarily harmless substances, causing sneezing; a runny nose; itchy, watery eyes and sometimes hives.

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How Allergies Develop
Why do you develop allergies? Nobody knows for sure, although the tendency to develop allergies can be inherited from your parents. If one parent has allergic disease, the estimated risk of the child to develop allergies is 26%. The child's estimated risk grows to 52% if both parents have a history of allergy.

Scientists do know how a person develops allergies. The first thing that happens is you are exposed to a particular substance-for example, pollen from a ragweed plant. This substance makes its way to your nose, where your immune system detects it and, considering it a harmful invader, creates antibodies to fight that particular substance. These antibodies stay in your system, prepared for the next time they encounter that same allergen.

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The Histamine Connection
The next time you breathe ragweed pollen in - and every time after that - your body will manufacture more antibodies to fight it off. The antibodies stimulate cells ("mast cells") in the linings of your nose, eyes, throat, and lungs to release a chemical known as histamine. Histamine attaches to nearby blood vessels, causing them to swell, and secrete more fluid than usual. Histamine can also irritate nearby nerve endings, causing itching. Ultimately, histamine causes symptoms such as sneezing; itchy, watery eyes, and a runny nose. These symptoms are simply your body's attempt to expel the pollen it wrongly assumes is dangerous.

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Pollen and Allergies
Nearly 50 million Americans have some form of allergy. For some of these people, symptoms come and go with the pollination seasons of certain trees, grasses, or weeds. Pollen levels from these plants can vary day to day, depending upon several factors, including the weather. High pollen levels can, in turn, affect the severity of symptoms you experience. Seasonal allergies affect about 35 million Americans.

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Allergic Rhinitis
The term "allergic rhinitis," when translated, literally means "inflammation of the nose." (The term "rhinitis" is derived by combining the Greek word for nose ("rhinos") with the term "itis," which means inflammation.)

Seasonal allergic rhinitis has also been referred to as "hay fever," which is very misleading considering the fact that it has nothing to do with hay or a fever. Dr. John Bostock, a British physician who suffered from allergies and noted a correlation between his symptoms and the British haying season, coined the term in the early 1800s.

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Perennial allergies
When allergy symptoms are caused by year-round allergens, the condition is termed "perennial rhinitis."

Important allergens that should be avoided include the following:

  • Dust mites, specifically mite feces, which are coated with enzymes that contain a powerful allergen. These are the primary allergens in the home.
  • Animal dander (flakes of skin) and hair, including from cats and dogs. Cats pose the greatest risk of all common pets.
  • Molds
  • Cockroaches are major allergy triggers

If you suffer from allergies, it is important to keep in mind that your symptoms may be caused by more than one substance-or a mixture of both perennial and seasonal allergens. In fact, that's why it can be tricky to avoid the things that trigger your allergies!

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CLARINEX®, a prescription medication, treats year-round allergy symptoms and ongoing hives of unknown cause, in adults and children 6 months and older, and seasonal allergy symptoms in patients 2 years and older. CLARINEX® 5 mg Tablets and 5 mg RediTabs® Tablets are approved for patients 12 years and older; CLARINEX® 2.5 mg RediTabs® Tablets are approved for patients 6 to 11 years; CLARINEX® Syrup is approved for patients 6 months and older.

Twice-daily CLARINEX-D® 12 HOUR Extended Release Tablets and once-daily CLARINEX-D® 24 HOUR Extended Release Tablets treat the symptoms of seasonal allergies, including nasal congestion, in patients 12 years and older.

IMPORTANT SAFETY INFORMATION
CLARINEX® Tablets side effects in patients 12 years and older were similar to placebo and included sore throat, dry mouth, and fatigue for seasonal and year-round allergy patients, and headache, nausea, and fatigue for patients with ongoing hives of unknown cause.

CLARINEX® Syrup side effects in children 6 to 11 years were similar to placebo. For children 6 months to 5 years, syrup side effects varied by age and included fever, diarrhea, upper respiratory infection, irritability, and coughing.

Due to their pseudoephedrine component, CLARINEX-D® 12 HOUR Extended Release Tablets and CLARINEX-D® 24 HOUR Extended Release Tablets should not be taken by patients with narrow-angle glaucoma (abnormally high eye pressure), difficulty urinating, severe high blood pressure, or severe heart disease, or by patients who have taken a monoamine oxidase (MAO) inhibitor within the past fourteen (14) days. Patients with high blood pressure; diabetes; heart disease; increased intraocular pressure (eye pressure); thyroid, liver or kidney problems; or enlarged prostate should check with their healthcare provider before taking CLARINEX-D® 12 HOUR Extended Release Tablets or CLARINEX-D® 24 HOUR Extended Release Tablets.

Care should be used if CLARINEX-D® 12 HOUR Extended Release Tablets or CLARINEX-D® 24 HOUR Extended Release Tablets are taken with other antihistamines or decongestants because combined effects on the cardiovascular system may be harmful. The most commonly reported adverse events for CLARINEX-D® 12 HOUR Extended Release Tablets were insomnia, headache, dry mouth, fatigue, drowsiness, sore throat, and dizziness. The most commonly reported adverse events for CLARINEX-D® 24 HOUR Extended Release Tablets were dry mouth, headache, insomnia, fatigue, sore throat, and drowsiness.

Click here for important CLARINEX® Tablets/Syrup/RediTabs® Product Information.
Click here for important CLARINEX-D® 12 HOUR Product Information.
Click here for important CLARINEX-D® 24 HOUR Product Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Note: The information on this site is not intended to be a substitute for professional medical advice. If you have any questions about your treatment or medical condition, please consult your doctor or other qualified health care provider. This site is intended for use by U.S. residents.

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